Yes. The San Francisco 49ers play at the Los Angeles Rams tonight, Thursday, September 10, kicking off at 8:35 PM ET. It’s the lone game on tonight’s NFL schedule, a divisional matchup between the two NFC West rivals.
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NFL Week 1 Games Schedule
Thursday, September 10
- 49ers vs. Rams, 8:35 PM (Netflix, Melbourne, Australia)
Sunday, September 13 — 1:00 PM
- Bears at Panthers (FOX)
- Buccaneers at Bengals (FOX)
- Saints at Lions (FOX)
- Ravens at Colts (CBS)
- Bills at Texans (CBS)
- Browns at Jaguars (CBS)
- Falcons at Steelers (FOX)
- Jets at Titans (CBS)
Sunday, September 13 — 4:25 PM
- Cardinals at Chargers (CBS)
- Packers at Vikings (CBS)
- Dolphins at Raiders (FOX)
- Commanders at Eagles (FOX)
Sunday, September 13 — 8:20 PM
- Cowboys at Giants (NBC, Peacock)
Monday, September 14
- Broncos at Chiefs, 8:15 PM (ESPN, ABC)
Week 1 runs September 9 to 14 and features 16 games, with no teams on bye. The 49ers vs. Rams game is the NFL’s first regular-season game played in Australia, at the Melbourne Cricket Ground.
Where to Play NFL Week 1 DFS and Props
NFL is prime territory for daily fantasy sports, since roster battles and limited snap counts create unpredictable value plays. DFS lineup picks breaks down which backups and bubble players are worth rostering across this Week 1 slate. For same-game and player-prop action, platforms like REBET and Prophet X offer markets on everything from first-drive outcomes to individual snap totals, giving bettors a way to stay engaged even in exhibition games where the box score doesn’t tell the whole story.
NFL Week 1 TV Channels
Most games air on NFL Network or ESPN, with select Sunday and Monday games on local/broadcast coverage (FOX). Check your local listings for games without a national broadcast partner.