Week 2 humbled everybody who bet favorites — us included, going 3-13 against the spread in a week where double-digit dogs kept winning outright and 2-0 teams kept losing straight up. Seattle blew out Arizona by 24, the Giants got run off their own field by the Rams a week after upsetting Dallas, and Chicago went from hanging 59 points to scoring 3. Three weeks in, records actually mean something now, so here’s where every team stands and a spread pick for all 16 games. Lines via DraftKings as of Sept. 21.
NFL Week 3 Picks At a Glance
| Matchup | Spread | Pick |
|---|---|---|
| Falcons at Packers | GB -7 | Packers -7 |
| Chiefs at Dolphins | KC -10 | Chiefs -10 |
| Panthers at Browns | CAR -2.5 | Panthers -2.5 |
| Bengals at Steelers | CIN -3.5 | Bengals -3.5 |
| Texans at Colts | HOU -1.5 | Colts +1.5 |
| Patriots at Jaguars | JAX -2.5 | Patriots +2.5 |
| Jets at Lions | DET -6.5 | Lions -6.5 |
| Titans at Giants | NYG -5.5 | Titans +5.5 |
| Chargers at Bills | BUF -7 | Bills -7 |
| Seahawks at Commanders | SEA -6 | Seahawks -6 |
| Vikings at Buccaneers | MIN -2.5 | Vikings -2.5 |
| Cardinals at 49ers | SF -8.5 | 49ers -8.5 |
| Ravens at Cowboys | BAL -3 | Cowboys +3 |
| Raiders at Saints | NO -3 | Raiders +3 |
| Rams at Broncos | LAR -2.5 | Rams -2.5 |
| Eagles at Bears | PHI -4.5 | Eagles -4.5 |
Thursday, Sept. 24
Falcons at Packers — Packers -7
Atlanta is 0-2 and scored three total points last week in a blowout loss to Carolina — that’s not a slump, that’s an offense that isn’t working. Green Bay needed overtime to get past the Jets, so this isn’t a great Packers team either, but there’s a real talent gap here that a home game at Lambeau should widen. Lay the touchdown.
Sunday, Sept. 27
Chiefs at Dolphins — Chiefs -10
Kansas City is 2-0, including an overtime road win at Indianapolis that showed some grit, and Patrick Mahomes looks fully back from the ACL tear. Miami is 0-2 and just got beaten by 22 on the road by San Francisco. That’s a big number to lay in September, and I’d trim it if I could shop a better line elsewhere, but on talent alone this isn’t close.
Panthers at Browns — Panthers -2.5
Carolina just hung 34 on Atlanta and Bryce Young has looked like a different quarterback through two weeks. Cleveland is 1-1, but the win over Tampa Bay needed a fourth-quarter push and this offense still isn’t consistently moving the ball. Small number, take the better offense on the road.
Bengals at Steelers — Bengals -3.5
Cincinnati is the last unbeaten team on this board outside Kansas City and San Francisco, and Joe Burrow’s had a clean two weeks. Pittsburgh scored three total points last week against New England — an offense that quiet is a real problem, not a blip. Lay the field goal and change.
Texans at Colts — Colts +1.5
Houston is 0-2 and has scored 31 and then 6 — wildly inconsistent, and the 6-point output came against a Bengals defense that isn’t a top-tier unit. Indianapolis lost in overtime to Kansas City, which is a much better loss than anything Houston’s produced. Take the home dog.
Patriots at Jaguars — Patriots +2.5
New England responded to a Week 1 blowout loss by beating Pittsburgh at home, 20-3, and Drake Maye didn’t turn the ball over. Jacksonville looked great in Week 1 and then lost on the road to Denver — the kind of letdown that makes me want the points against them the following week. Take New England.
Jets at Lions — Lions -6.5
Detroit’s coming off a letdown loss to Buffalo after that overtime opener, but this is still a more talented roster than a Jets team that just blew a lead and lost in overtime to Green Bay. Lay the number at home.
Titans at Giants — Titans +5.5
The Giants just got run off the field at home, 28-6, by the Rams — the kind of performance that should make you pump the brakes before laying almost a touchdown the following week. Tennessee’s 0-2 and its offense is a mess, but it played Philadelphia tight for a half last week. I’d rather take the points here than trust a Giants team that just had its worst game of the season.
Chargers at Bills — Bills -7
Los Angeles is 0-2 and has been outscored by a combined 26 points already. Buffalo’s 2-0 and averaging nearly 39 a game. This isn’t a hard one. Lay it.
Seahawks at Commanders — Seahawks -6
Seattle’s 2-0 and just blew out Arizona by 24 with Sam Darnold looking fully healthy again. Washington’s 0-2 and hasn’t found any rhythm on offense around Jayden Daniels. Lay the number on the road.
Vikings at Buccaneers — Vikings -2.5
Minnesota’s 2-0 without scoring much — a 9-3 defensive slugfest last week — but that defense has been the best story of the young season. Tampa Bay’s 0-2 with both losses coming by single scores, which says the roster’s competitive but still finding ways to lose close ones. Take the better defense.
Cardinals at 49ers — 49ers -8.5
Arizona looked good in Week 1 and then got smoked by Seattle, 31-7, in Week 2 — that’s the version of this team I trust less. San Francisco’s 2-0 and has outscored opponents by 24 points a game. Big number, but lay it.
Ravens at Cowboys — Cowboys +3
Baltimore lost at home to New Orleans last week, which is the kind of result that should cost a team its favorite status on the road the next week, not just get shrugged off. Dallas responded to its Week 1 loss with a 17-point win over Washington. I’ll take the home dog here.
Raiders at Saints — Raiders +3
Las Vegas is 2-0 and has been one of the better stories of the season so far, running the ball effectively both weeks. New Orleans is 1-1 off an emotional win over Baltimore, but I’m not laying points against an undefeated team on the road just because the home team had one good week. Take the Raiders.
Sunday Night, Sept. 27
Rams at Broncos — Rams -2.5
Los Angeles bounced back from the Melbourne blowout in the best way possible, beating the Giants 28-6. Denver’s 1-1 after a solid road win at Jacksonville, but the Rams looked like the better overall roster even in that ugly Week 1 loss. Lay the field goal on the road.
Monday Night, Sept. 28
Eagles at Bears — Eagles -4.5
Philadelphia’s 2-0, though it’s needed the fourth quarter to close out both wins. Chicago went from 59 points in Week 1 to 3 points in Week 2 against Minnesota — that’s an offense that hasn’t figured out how to be consistent yet. Lay the number on the road.
Odds via DraftKings Sportsbook as of Sept. 21, 2026, and subject to change before kickoff. This content is for informational purposes only. Gambling problem? Call 1-800-GAMBLER.