College Football Week 11 Picks 2026: Predictions Against the Spread for the Biggest Games

Miami lost and Ohio State lost again. This season is making no sense and I am loving it. Notre Dame beat the Canes 31-24, and Oregon went into Columbus and dropped 41 on the Buckeyes. This week we’ve got Texas at LSU, USC at Indiana and Utah at Arizona.

Let’s take a look at my picks, and if you want to see how I’ve done in the past, check out my Week 6 college football picks against the spread.

College Football Week 11 Picks ATS

MatchupSpreadPick
Duke at MiamiMIA -13.5Duke +13.5
Northwestern at Ohio StateOSU -12.5Northwestern +12.5
Wake Forest at SMUWAKE -1.5Wake Forest -1.5
Tennessee at Texas A&MTENN -2.5Tennessee -2.5
Missouri at GeorgiaUGA -15.5Georgia -15.5
USC at IndianaIND -7.5USC +7.5
Michigan at OregonORE -11.5Oregon -11.5
Florida at KentuckyUK -3.5Florida +3.5
Utah at ArizonaUTAH -2.5Utah -2.5
Texas at LSULSU -3.5Texas +3.5

Saturday, Nov. 14 (Noon)

Duke at Miami – Duke +13.5

Miami was down 24-3 at Notre Dame before they woke up. They managed to close the gap but still lost. Duke’s 7-2 and they aren’t making a splash. Giving up almost two touchdowns to Miami feels like too much. Duke plus the points is the smart move.

Northwestern at Ohio State – Northwestern +12.5

Ohio State has lost two straight games and Oregon just put up 41 on them at home. Yeah, you read that right. Northwestern actually beat Oregon a couple weeks ago. Go with Northwestern for the money.

Wake Forest at SMU – Wake Forest -1.5

Wake Forest has won five games in a row, all by 20 points or more. The only team that has managed to beat them is Miami. SMU’s defense has given up 28 in back to back games to some pretty average offenses. At a basic pick em take Wake Forest.

Saturday Afternoon

Tennessee at Texas A&M – Tennessee -2.5

Tennessee kicked Kentucky’s a** 34-6, and Kentucky was 7-1 going into that one. A&M is 4-5 and hasn’t beaten a ranked team all year. The total’s low so that means it’ll probably be ugly. I’ll lay the 2.5 with the better defense. A&M’s season has also kept the next college football coach fired odds conversation going for a few sideline hot seats around the country.

Missouri at Georgia – Georgia -15.5

Georgia was up 28-0 at halftime in Oxford last week, and Ole Miss had 37 rushing yards at the break. A few weeks ago Missouri lost to that same Ole Miss team 31-3. Even though 15.5 is a big number, I don’t see Missouri scoring much in Athens.

USC at Indiana – USC +7.5

USC beat Ohio State by 12 and Jayden Maiava has been really good. Indiana’s defense is no joke, but that offense still scares me after the 13-6 overtime win at Michigan. I think more than a touchdown is too much. Take USC plus the points.

Michigan at Oregon – Oregon -11.5

Oregon scored 41 at Ohio State. Michigan scored 6 against Michigan State. The total is 38.5, proving that even Vegas doesn’t think Michigan can score. Taking the Ducks all the way.

Saturday Night

Florida at Kentucky – Florida +3.5

Kentucky only put up 6 points at Tennessee. When that offense goes cold, it goes really cold. I’m not saying Florida’s great at 5-4, they definitely aren’t. Going to have to take more than a field goal here.

Utah at Arizona – Utah -2.5

Utah’s 9-0 and they finally beat BYU for the first time since 2019. Yeah, it’s a road game after a big rivalry win, and those are always tricky. But Arizona hasn’t beaten a ranked team yet. Utah under a field goal works for me.

Texas at LSU – Texas +3.5

This is the first time Texas and LSU have ever played as SEC teams. Texas has won three straight and is 4-0 against ranked teams. LSU just got pushed around at home by Bama, 31-13. Give me Texas and the points. Let’s be honest, I would take Texas straight up. If you’d rather back your picks on a prediction market, see the latest prediction market sports promos.

Odds via DraftKings Sportsbook as of Nov. 11, 2026, and subject to change before kickoff. This content is for informational purposes only. Gambling problem? Call 1-800-GAMBLER.

Manuel Mora Avatar

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