What a week! We went 12-3 in Week 9, and our only misses were the Jets, the Cardinals and a Bears team that almost made it. Moving on to Week 10, let’s take a look at the 14 games.
So much going on, a trip to Munich with a 9:30 a.m. ET kickoff, a Giants home game Thursday night, and a Steelers-Bengals showdown Sunday night with both teams at 6-2. If you’re getting set up for the weekend, see our guide to the best NFL betting apps.
NFL Week 10 Picks ATS
| Matchup | Spread | Pick |
|---|---|---|
| Commanders at Giants | NYG -2.5 | Giants -2.5 |
| Patriots vs. Lions (Munich) | DET -2.5 | Lions -2.5 |
| Chiefs at Falcons | KC -3.5 | Chiefs -3.5 |
| Texans at Browns | HOU -4.5 | Texans -4.5 |
| Vikings at Packers | GB -5.5 | Vikings +5.5 |
| Dolphins at Colts | IND -2.5 | Colts -2.5 |
| Panthers at Saints | NO -1.5 | Saints -1.5 |
| Bills at Jets | BUF -8.5 | Bills -8.5 |
| Jaguars at Titans | JAX -10.5 | Titans +10.5 |
| Seahawks at Raiders | SEA -3.5 | Raiders +3.5 |
| Rams at Cardinals | LAR -9.5 | Rams -9.5 |
| 49ers at Cowboys | SF -4.5 | 49ers -4.5 |
| Steelers at Bengals | CIN -3.5 | Steelers +3.5 |
| Chargers at Ravens | BAL -5.5 | Chargers +5.5 |
Thursday, Nov. 12
Commanders at Giants – Giants -2.5
The Giants are 5-2-1 and just won in Philadelphia for the first time since 2013. J.J. McCarthy got hurt in that last game, so his status is worth a check before kickoff. Washington is 2-5-1 and lost to the Rams. I’m laying the 2.5 and backing the Giants.
Sunday, Nov. 15 (Munich)
Patriots vs. Lions – Lions -2.5
This is the last European game of the year, and it kicks off at 9:30 a.m. ET, so brew the coffee and enjoy. Detroit is 6-2 and just held Miami to nine points. New England got run over by Green Bay, 45-27, and that defense is weak to say the least. Give me the Lions minus the points.
Sunday, Nov. 15
Chiefs at Falcons – Chiefs -3.5
Kansas City stumbled in Denver, then went on to roll the Jets 35-12. Mahomes bent his elbow on a strip-sack and came right back. That tells me all I need to know. Atlanta is 3-6 after losing 34-17 to Cincinnati in Madrid. Chiefs by a touchdown feels like the right pick to me.
Texans at Browns – Texans -4.5
C.J. Stroud threw for 384 yards and five touchdowns against the Chargers. Yes, it was the Chargers, but still impressive. Cleveland lost in overtime to New Orleans, 23-22, and that offense can’t seem to stay consistent. Add to all of this that Will Anderson Jr. leads the league in sacks, I’ll lay it.
Vikings at Packers – Vikings +5.5
Green Bay scored 45 last week, so yeah, I can see the case. Here’s the thing: Minnesota is still 6-2, and 5.5 is a lot to give in a rivalry game. The offense managed just six points against Buffalo, which is the risk here. I’ll take the points anyway.
Dolphins at Colts – Colts -2.5
Welcome to the basement. This is as low as it gets. Miami is 1-7, Indianapolis is 2-7. The Colts at least put up 23 on Dallas, while the Dolphins only scored nine against the Lions. I’m taking Indy, but I don’t feel great about it. If you’re curious where the Colts’ skill players could land, check out the Jonathan Taylor next team odds.
Panthers at Saints – Saints -1.5
Both teams are 3-5. New Orleans just beat Cleveland in overtime, and Carolina lost 26-21 to Denver. Home field advantage is the tiebreaker for me. Saints all the way.
Bills at Jets – Bills -8.5
Buffalo is 7-1 and just held Minnesota to six points. On the other hand the Jets are 2-7 and got run out of Kansas City, 35-12. Nine is a lot, but I don’t see New York keeping pace. Take the Bills.
Jaguars at Titans – Titans +10.5
Jacksonville has been rolling. It beat Baltimore 33-10 on Thursday and Indianapolis 42-7 before that. Tennessee had a bye to reset, and 10.5 on the road is a big ask of anybody, even Jacksonville. The Titans are 1-7, so this could get ugly. I’ll take the points anyway.
Sunday Afternoon, Nov. 15
Seahawks at Raiders – Raiders +3.5
Seattle won 17-3 over Arizona, but Drew Lock started with Sam Darnold out, and he did get hurt during the game. If the quarterback situation is a mess, 3.5 on the road is way too many points. The Raiders got smoked 38-17 by San Francisco, so I’m not in love. Going to have to go with Raiders and the points.
Rams at Cardinals – Rams -9.5
Arizona scored three points against Seattle, and Gardner Minshew took a shot to his throwing arm. The Rams are 5-4 and beat Washington 20-13. Almost ten is a big number, but I’m not getting much from that Arizona offense. Rams to win it. Arizona’s pass rush could look different soon, too, so see the Josh Sweat next team odds.
49ers at Cowboys – 49ers -4.5
Dallas beat Indy 27-23, and I still don’t trust that defense after blowing a 14-point lead to Arizona the week before. San Francisco is 7-1 after dropping 38 on Las Vegas. This number looks short to me and I am throwing in with Dallas.
Sunday Night, Nov. 15
Steelers at Bengals – Steelers +3.5
This game is a nail biter. Two 6-2 teams, and I’m getting 3.5 points with Pittsburgh coming off a bye. Joe Burrow was great in Madrid, 24-of-29 with three touchdowns, so yeah, I get it. Still, a rested team getting that many points in a game this tight makes it obvious to me. Want to back your picks on a prediction market? See the prediction market NFL promos.
Monday Night, Nov. 16
Chargers at Ravens – Chargers +5.5
Los Angeles is 0-8 and, yeah, it’s the Chargers. But Baltimore is 4-5, down Lamar Jackson, and just lost 33-10 at home to Jacksonville. Hard to lay almost a touchdown with that offense. I’ll take the points and brace for disaster.
Odds via DraftKings Sportsbook as of Nov. 9, 2026, and subject to change before kickoff. This content is for informational purposes only. Gambling problem? Call 1-800-GAMBLER.
